The incident happened at 10.30pm last night in Avignon, Provence.
Two hooded men pulled up in a Renault Clio and began firing at worshipers, who were leaving Arrahama.
The gunmen fled the scene and French police have launched a manhunt
One of the attackers was carrying a handgun, while the other had a rifle.
Four people were hurt at the scene and a family-of-four, on the second floor of a nearby apartment, received shrapnel wounds. Among the injured was a seven-year-old girl.
The gunmen fled the scene and French police have launched a manhunt.
The incident comes just two weeks after one person was killed and nine others injured in a terrorist attack outside a mosque in Finsbury Park, London.
In addition, a man was arrested on Thursday after trying to drive a car into a crowd in front of a mosque in the Paris suburb of Creteil. No one was injured in the incident.
France is on high security alert following a series of militant attacks in recent years.
Laure Chabaud, an Avignon magistrate, said police suspected it was a gangland dispute.