More than 250 friends and family - including some of football's biggest stars - have jetted to Argentina, cars are waiting at the airport to whisk them to the venue while the bride's dress arrived from Spain by private jet accompanied by two bodyguards.
At the plush hotel complex where the couple will marry, mobile phones have been banned, staff sworn to secrecy and 450 police officers drafted on duty.
However there is one aspect which may overshadow the 30-year-old Barcelona star's big day – claims of tension between his close-knit family and the woman he fell in love with at the age of five.
A source close to the Messi family has told MailOnline that relations between his family and fiancée Antonella Roccuzzo have been strained for nearly seven years.
The friend said that while the two families might appear united during tonight's luxurious celebrations there has been tension in the past.